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Showing posts with label disease. Show all posts
Showing posts with label disease. Show all posts

Wednesday, February 12, 2025

The Spike as Autoimmune Pied Piper

 

The Spike as Autoimmune Pied Piper: After Invading the Endothelium, the Spike Induces Autoimmune Disease via an Integrin-Mediated Mechanical Process

The RGD sequence in the Spike Protein provides a comprehensive and convincing explanation for the Spike invading organs and inducing autoimmune disease.

Integrin-mediated immune cell adhesion to endothelial cells under a shear force of blood flow. (A) Migration of immune cells under force—immune cells traveling through the blood vessel experience a shear force of the blood flow. Chemokines (green) are secreted by the endothelial cells lining the tissue displaying self-antigens; however, the chemokine gradient is highest near the infectious tissue. The chemokines slow down the flow rate of the migratory leukocytes towards the site of infection under the shear stress of blood flow, equivalent to 1 dyn/cm2. (B) Slip-bond formation and decrement in cell migration velocity—cells gradually decrease the speed along with the rise of chemokine gradient and tumble on the endothelial cells of the blood vessel. The selectin molecules, expressed by the leukocyte, interact with its counterpart expressed on the endothelial cells. However, their interaction under a shear force of blood flow causes the slippage of the bonds, allowing the cell to roll on the endothelial layer, while rolling numerous numbers of slip bond forms and breaks between the molecules like P-selectin, E-selectin, PSGL1, E-cadherin, etc. (C) Extended-closed integrins—the GPCR expressed on the leukocytes interacts with the chemokine to activate PI3K that induces Rap1–RIAM complex to activate talin for further binding with the β subunit cytosolic tail of integrin. This partially activates integrin from its bent-closed to extended-closed structure. (D) Integrin activation leading to focal adhesion—the extended-closed integrin gets activated, either by outside-in signaling by interacting with CAM while rolling on the endothelial layer or by inside-out signaling through sensing the force from talin–actin complex. The activation breaks the integrin salt bridge, transforming it into a thermodynamically unstable but active extended-open conformation. This forms integrin–ligand catch bonds under blood-flow shear force, resulting in complete adhesion of the immune cells to the endothelial layer. During this interaction, the force is transmitted through integrin both outside and inside the cell, which finally transduces downstream forming the focal adhesion. (E) Adhesion of cell—this focal adhesion regulates the cell's shape and migration and strictly adheres the cell on the endothelial layer by inducing the catch-bond formation. (F) Diapedesis—while remaining attached on the endothelial surface in the infected tissue, the self-reactive immune cells transmigrate in between adjacent cells by diapedesis towards the infected tissue region (Zhu et al., 2007b; Jahed et al., 2014; Huse, 2017). 



Monday, August 26, 2024

Northeastern towns issue voluntary lockdow

 

Northeastern towns issue voluntary lockdown to prevent spread of potentially deadly mosquito-borne disease EEE

Wednesday, August 3, 2022

STUDY: Face masks are teeming with disease-causing bacteria and fungi

STUDY: Face masks are teeming with disease-causing bacteria and fungi

(Natural News) Japanese researchers just published a paper in the journal Scientific Reports that deconstructs the false notion that face masks protect against infection and spread of the Wuhan coronavirus (Covid-19).

It turns out that face masks are petri dishes for pathogens to fester and multiply, whether they be the Fauci Flu, the common cold, or a fungal infection. If it causes illness, it will find a home in the mesh of a face mask, the study found.

“Since masks can be a direct source of infection to the respiratory tract, digestive tract, and skin, it is crucial to maintain their hygiene to prevent bacterial and fungal infections that can exacerbate COVID-19,” the authors gently wrote.

One of the first studies to address the hygiene issues associated with wearing a mask, the paper looked at 109 participants between the ages of 21 and 22 who wore a mask between September and October of 2020, the height of the plandemic.

Each participant was asked about the type of mask used, as well as how long, on average, it was worn. Researchers then collected bacteria and fungi from the three types of masks identified: gauze, polyurethane (plastic), and non-woven.

What they discovered is that bacteria tended to fester inside the masks where they are closest to the face while the outside of the masks tended to harbor more fungi. (Related: Dozens of scientific studies show that face masks increase the risk of disease and death.)

The longer a mask is worn, the researchers further discovered, the more that bacteria and fungi multiply.

“[F]ungi and their spores are resistant to drying,” the paper explains. “[T]hey can survive under the condition where masks dry out.”

No matter what type of mask is used, bacteria and fungi love it

The worst offenders were the plastic and gauze masks, which were found to contain far more fungal colony counts than the non-woven mask type, which have three layers: two layers of fabric sandwiching a non-woven middle layer filter.

Washable and reusable masks were no better, the researchers also discovered, much to their surprise.

“The proper cleaning method for cotton face masks has been recommended to reduce the microbial load on the masks,” they wrote.

“However, in the current experiments, we did not find significant differences in bacterial or fungal colony numbers on the masks based on washing.”

Regardless of which type of mask a person uses, what he or she does every day, the duration and mode of travel to and from work and other places, etc., the risk of being exposed to dangerous pathogens is pretty much the same.

“We found no differences in the bacterial or fungal colony counts on both sides of the masks among the three transportation systems,” the authors explained after looking at masks through the lens of public transportation, personal vehicle use and walking or biking.

Even if a person gargles once and day and takes other attempted protective measures to keep a mask clean, it will still accumulate bacteria and fungi just the same, the paper further reveals.

While some of the bacteria and fungi identified are generally harmless, others are linked to food poisoning symptoms and staph infections. In the case of fungi, those that build up on masks are linked to things like ringworm, athlete’s foot and jock itch.

In their conclusion, the authors wrote that people should “avoid repeated use of masks to prevent microbial infection,” especially if they have a weakened immune system.

“To date, the evidence has been stable and clear that masks do not work to control the virus and they can be harmful and especially to children,” says Dr. Paul Alexander, an epidemiologist and researcher.

The latest news about Fauci Flu face veils can be found at BadMedicine.news.

Sources for this article include:

TheEpochTimes.com

NaturalNews.com

Source: https://www.naturalnews.com 

 

Tuesday, November 2, 2021

SCIENCE HORROR: Vaccine spike protein enters cell nuclei, suppresses DNA repair engine of the human body

SCIENCE HORROR: Vaccine spike protein enters cell nuclei, suppresses DNA repair engine of the human body, will unleash explosion of cancer, immunodeficiency, autoimmune disorders and accelerated aging

Image: SCIENCE HORROR: Vaccine spike protein enters cell nuclei, suppresses DNA repair engine of the human body, will unleash explosion of cancer, immunodeficiency, autoimmune disorders and accelerated aging

 

(Natural News) This finding can only be described as a true “horror” in its implications. Stunning new research published in Viruses, part of the SARS-CoV-2 Host Cell Interactions edition of MDPI (Open Access Journals) reveals that vaccine spike proteins enter cell nuclei and wreak havoc on cells’ DNA repair mechanism, suppressing DNA repair by as much as 90%.

The research paper is entitled, “SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro” and is authored by Hui Jiang and Ya-Fang Mei, at the Department of Molecular Biosciences, The Wenner–Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden, and the Department of Clinical Microbiology, Virology, UmeÃ¥ University, SE-90185 UmeÃ¥, Sweden, respectively.

We have saved a copy of the research paper in a PDF document on NN servers at this URL:
https://www.naturalnews.com/files/viruses-13-02056-v2.pdf

In the conclusion of the paper, authors write, “We found that the spike protein markedly inhibited both BRCA1 and 53BP1 foci formation (Figure 3D–G). Together, these data show that the SARS–CoV–2 full–length spike protein inhibits DNA damage repair by hindering DNA repair protein recruitment.”

The DNA repair mechanism, known as NHEJ (Non-Homologous End Joining) is a kind of intracellular “emergency response” system that repairs double-stranded DNA breaks. Without the NHEJ mechanism, all advanced multi-cellular life would cease to exist. No human being, animal or plant can survive with the integrity of its genetic code being protected and constantly repaired through multiple mechanisms.

DNA damage can be caused by exposure to radiation, chemicals found in foods and personal care products, or even exposure to mammography equipment. Excessive sunlight exposure can also cause DNA breaks, and minor DNA mutations occur spontaneously in all living organisms. Airline pilots, for example, are routinely exposed to ionizing radiation due to flying at altitude.

In a normal, healthy person, the NHEJ mechanism repairs the DNA and prevents a pathogenic mutation from occurring. But in the presence of the vaccine spike protein, NHEJ effectiveness is suppressed by as much as 90%, meaning it is unable to do its job due to the suppressed ability to recruit proteins for repair.

As a result, the following “errors” are introduced into chromosomes inside the nuclei of human cells, all due to the presence of the spike protein from mRNA vaccines:

  • Mutations or “errors” in the genetic sequence.
  • DELETIONS of entire segments of genetic code.
  • INSERTIONS of incorrect segments.
  • Mixing and matching / permutations of genetic code.

These errors, when expressed through cell division and replication, result in:

  • An explosion of cancer and cancer tumors throughout the body
  • Loss of production of immune system B and T cells (i.e. induced immunodeficiency)
  • Autoimmune disorders
  • Accelerated aging and reduced telomere length
  • Loss of functioning of complex organ systems such as circulatory, neurological, endocrine, muskuloskeletal, etc.
  • Cellular damage resembling radiation poisoning as cells destroy themselves from within

Many of these effects are, of course, fatal. Others will burden vaccine victims with horrendous debilitating injuries and organ malfunctions that will require a lifetime of medical intervention.

Spike protein goes into the nucleus of the cell

From the paper linked above:

Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site.

This means that the spike protein, which is generated in cell ribosomes after the cells have been hijacked by mRNA vaccines, doesn’t always leave the cell and enter the bloodstream as we are told by mRNA vaccine proponents. In some cases, the spike protein enters the cell nucleus. There, it interferes with the DNA repair mechanism as described throughout this article.

“Surprisingly, we found the abundance of the spike protein in the nucleus (Figure 1A),” concluded study authors.

This means, without question, mRNA vaccines result in chromosomal alterations in the body’s cells. It is confirmation that such vaccines are, indeed, wreaking havoc with genetic integrity and are exhibiting side effects that have not been anticipated or described by mRNA vaccine proponents.

Dr. Thomas Levy writes about the toxicity of the spike protein on Orthomolecular.org:

Concern has been raised regarding the dissemination of the spike protein throughout the body after vaccination. Rather than staying localized at the injection site in order to provoke the immune response and nothing more, spike protein presence has been detected throughout the body of some vaccinated individuals. Furthermore, it appears that some of the circulating spike proteins simply bind the ACE2 receptors without entering the cell, inducing an autoimmune response to the entire cell-spike protein entity. Depending on the cell type that binds the spike protein, any of a number of autoimmune medical conditions can result.

More alarmingly, Dr. Levy explains that current evidence shows the spike protein continues to produced in the body, following the initial mRNA injection. He explains:

While the underlying pathology remains to be completely defined, one explanation for the problems with thrombotic tendencies and other symptomatology seen with chronic COVID and post-vaccination patients relates directly to the persistent presence of the spike protein part of the coronavirus. Some reports assert that the spike protein can continue to be produced after the initial binding to the ACE2 receptors and entry into some of the cells that it initially targets. The clinical pictures of chronic COVID and post-vaccine toxicity appear very similar, and both are likely due to this continued presence, and body-wide dissemination, of the spike protein (Mendelson et al., 2020; Aucott and Rebman, 2021; Levy, 2021; Raveendran, 2021).

Full-length spike protein resulted in the greatest suppression of NHEJ DNA repair mechanism

See the figures below. SARS-CoV-2 viral fragments are named “Nsp1, Nsp5” and so on. The full-length spike is called “Spike” and the nucleocapsid — another structural part of the whole spike protein pathogen — is identified separately.

From the study:

Overexpression of Nsp1, Nsp5, Nsp13, Nsp14, and spike proteins diminished the efficiencies of both HR and NHEJ repair (Figure 1B–E and Figure S2A,B).

Figures C and E show the suppression of NHEJ repair by these various portions of viral fragments. (See the blue vertical graph lines representing activity / efficiency levels of the DNA repair mechanism).

 

What these data show is that the greatest suppression of NHEJ activity is measured when the full spike protein is present. From the study:

Together, these data show that the SARS–CoV–2 full–length spike protein inhibits DNA damage repair by hindering DNA repair protein recruitment.

This is the spike protein that’s generated by the body’s own cells after being injected with an mRNA vaccine:

In figure 2, below, we see that the suppression of NHEJ activity exhibits a dose-dependent response to the presence of spike protein (figures 2B and 2C). This indicates that the more spike proteins are present, the greater the suppression of DNA repair:

 

The bottom right figure, 2G, shows how the presence of the spike protein inhibits DNA repair following various insults to the DNA, such as radiation, chemical exposure or oxidation. Importantly, as the study authors explain:

Following different DNA damage treatments, such as ?–irradiation, doxorubicin treatment, and H2O2 treatment, there is less repair in the presence of the spike protein (Figure 2F,G). Together, these data demonstrate that the spike protein directly affects DNA repair in the nucleus.

5G exposure, chemtrail exposure, food chemical exposure, mammography and even sunlight exposure will wreak havoc in those who have taken mRNA vaccines

The horrifying upshot of this finding is that people who have taken mRNA vaccines will experience suppressed DNA repair, escalating exposures that were once thought to be minor issues to significant threats to their health.

In other words, people exposed to 5G radiation, mammography exams, plasticizer chemicals in food products, and carcinogens in personal care products (laundry detergents, perfumes, shampoos, skin lotions, etc.) will be unable to repair the DNA damage caused by those exposures. Following relatively small exposures, they will begin to mutate and develop cancers throughout their bodies.

Don’t forget that 5G exposure results in peroxynitrite production in the blood, an extremely dangerous free radical that causes DNA damage in brain cells and tissue cells across the body.

This could even be described as a kind of binary weapon system where mRNA vaccines weaken DNA repair, and 5G exposure (or chemical exposure in the food supply) provides the weapon that breaks DNA strands and leads to the body being unable to maintain genetic integrity during cell replication. This doesn’t take long to be expressed in horrific physical ways, such as the attempted growing of internal organ tissues on the surface of the skin or face, which is why I have titled today’s Situation Update podcast, “Monsters, Zombies and Mutants.”

The presence of the spike protein interferes with normal immune function and leads to immunodeficiency (an AIDS-like condition)

This research also finds that spike proteins from mRNA vaccines can lead to immunodeficiency conditions, similar to AIDS. This is consistent with what we have previously reported about immune function dropping roughly 5% per week in those who have taken covid vaccines. From the study:

…[L]oss of function of key DNA repair proteins such as ATM, DNA–PKcs, 53BP1, et al., leads to defects in the NHEJ repair which inhibit the production of functional B and T cells, leading to immunodeficiency.

Immune function is also critically affected by the presence of the spike protein, potentially leading to cancerous mutations throughout the body’s cells. As the study explains:

DNA damage repair, especially NHEJ repair, is essential for V(D)J recombination, which lies at the core of B and T cell immunity.

As Science Direct also explains:

Maintaining genomic integrity is imperative for the survival of an organism. Among different DNA damages, double-strand breaks (DSBs) are considered as most deleterious since they can lead to cell death if left unrepaired or chromosomal rearrangements when mis-repaired, leading to cancer.

Further, mutations in NHEJ genes including Ku70 and Ku80 have been associated with shortened life spans in mice [54]. In addition, defects in DNA-PKcs (DNA-dependent protein kinase) resulted in impaired telomere maintenance and shortened life span in mice [55]. Taken together, these lines of evidence suggest that NHEJ plays an important role in preventing age-related increase in genomic instability and functional decline.

In effect, this means the spike protein’s suppression of the NHEJ DNA repair mechanism also leads to reduced lifespan and accelerated aging.

By some estimates, 50% of the people injected with mRNA vaccines will be dead within five years. Now we have a deeper understanding of the mechanisms by which those vaccine-induced fatalities may occur.

Hear the verbal explanation of all this in today’s Situation Update podcast:

Brighteon.com/cb351cd3-6c94-4f2b-a05d-bbda757d4472

Source:  Natural News

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